What is a "Cell Signal Disruptor"? The Most Authoritative Explanation.

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What is a "Cell Signal Disruptor"? The Most Authoritative Explanation.

What is cell disruption?

Cell disruptionis the process of breaking open (otherwise known as lysing) cells in order to obtain the intracellular fluid (commonly referred to as lysate). There are a variety of intracellular components that may be desired to obtain via cell disruption, including proteins and viral vectors that are not expressed extracellularly.

What are some examples of disrupted cell signalling in disease?

Some examples of disrupted cell signalling in disease include: Cancer cells have constant activation of signalling pathways instructing the cells to grow and divide. This often occurs because of changes (mutations) in receptors, protein kinases or transcription factors that keep the proteins an active state.

What is cell signalling and how does it work?

Cell signalling refers to the translation of an external signal into a cell’s response. External signals can include: Direct contact with other cells or structures. Molecules that are secreted by other cells. Viral or bacterial infections.

What are our researchers doing to investigate cell signalling?

Our researchers are investigating cell signalling in healthy cells, to understand what goes wrong to cause disease. Particular foci of our research are: Investigating proteins that enable cell signalling, and how these signals are switched off.


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